Table 1. In Vivo Exposure Data for Ketamine.

Time	1 mg/kg, i.v.	3 mg/kg, i.v.	10 mg/kg, i.v.	30 mg/kg, i.v.
Ketamine plasma exposure (nM; mean±SD; n=3)
7 min	436±89	1111±258	9149±1811	72 544±57 164
32 min	212±150	289±226	1150±57.3	5181±1410a
62 min	50±15	99±61	438±73	2110±434
Ketamine brain exposure (nM; mean±SD; n=3)
7 min	1199±170	3912±1055	26 124±5959	103 147±28 066
32 min	895±636	836±426	4242±1531	16 941±5671a
62 min	163±95	203±110	1106±83	5782±1356

^aData from two subjects.