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. 2016 Mar 16;41(9):2283–2293. doi: 10.1038/npp.2016.27

Figure 4.

Figure 4

Effects of rimonabant or AM4113 on priming-induced reinstatement of drug seeking in monkeys. During the extinction sessions, saline was substituted for drug (nicotine, THC, or cocaine). During test sessions, rimonabant (0.03–0.3 mg/kg), AM4113 (0.1–1 mg/kg), or vehicle was injected i.m. before priming injection (i.v.) of nicotine ((a, b, e, h) 0.1 mg/kg; n=3), THC ((c, f, i) 0.04 mg/kg), cocaine ((d, g, j) 0.1 mg/kg), or vehicle. Numbers of lever-presses emitted during the 1 h sessions upon completion of a FR10 schedule are shown (mean±SEM; n=3–4). *P<0.05, different from the ‘Vehicle' condition; #p<0.05, different from the ‘Nicotine 0.1,' ‘THC 0.04,' or ‘Cocaine 0.1' condition, respectively. Nic, nicotine; Coc, cocaine; rim, rimonabant; AM, AM4113.