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. 2016 Mar 16;41(9):2309–2323. doi: 10.1038/npp.2016.33

Figure 2.

Figure 2

Repeated stress decreases GABAergic inhibition. Spontaneous inhibitory postsynaptic current (sIPSCs) were measured from lateral nucleus (LAT) principal neurons ex vivo to gauge ongoing GABAergic inhibition from synaptic sources. (a) Repeated stress decreased the frequency of sIPSCs in this example from an adult rat. (b) Repeated stress decreased the frequency of sIPSCs in this example from an adolescent rat. (c) Repeated stress significantly decreased the frequency of sIPSCs in adult and adolescent rats (left; *p<0.05, Holm–Sidak's multiple comparisons test after significance in two-way analysis of variance (ANOVA). Repeated stress significantly decreased the amplitude of sIPSCs in adult and adolescent rats (right; *p<0.05, Holm–Sidak's multiple comparisons test after significance in two-way ANOVA).