Skip to main content
. 2016 Mar 16;41(9):2309–2323. doi: 10.1038/npp.2016.33

Figure 4.

Figure 4

Repeated stress impairs the lateral nucleus (LAT) neuronal response to γ-aminobutyric acid (GABA) in adolescent rats. LAT neurons were induced to fire at ~ 5 Hz with iontophoretic application of glutamate. Inhibition caused by coiontophoretic application of GABA was measured in vivo (5–40 nA dose–response). (a) In adult rats, repeated stress had no significant effect on the response of LAT neurons to iontophoretic GABA. (b) In adolescent rats, repeated stress significantly weakened the effect of iontophoretic GABA on LAT neuron firing (*p<0.05, Holm–Sidak's multiple comparisons test after significance in a two-way repeated-measures analysis of variance (ANOVA). (c) The magnitude of the effect of stress on GABA-induced inhibition was significantly greater in adolescent rats (**p<0.05 in a two-way repeated-measures ANOVA).