Figure 6.

HTP is absorbed by the mouse colon. (a) 5-HTP_Plasma and (b) 5-HIAA_Plasma levels following injection of 5-HTP (10 mg/kg) into the jejunum or colon lumen (N=8). (c) Phenol Red_Plasma levels following injection of Phenol Red (10 mg/kg) into the jejunum or colon lumen (N=6). Phenol Red served as a poorly absorbed reference compound. Data represent means±SEM. Only WT mice were used. (a–c) Two-way repeated-measures ANOVA followed by Bonferroni's post-hoc test. *p<0.05, jejunum vs colon. Additional statistical information is available in Supplementary Table S1.