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. 2016 Apr 27;41(9):2377–2387. doi: 10.1038/npp.2016.45

Figure 3.

Figure 3

Increasing expression of 5-HT6 receptors in iMSNs shifted the dose-preference curve downward. (a) Dose-dependent cocaine infusion (mean±SEM) for rats with Dyn-GFP or Dyn-5-HT6 (Dyn-5-HT6, n=4–8 depending on dose; Dyn-GFP n=4–7 depending on dose) at three unit doses of cocaine infusion (0.375, 0.75, and 1.5 mg/kg/infusion) (two-way ANOVA, F(1,29)=0.77, p=0.39). (b) Total cocaine received (mean±SEM) for rats with Dyn-GFP or Dyn-5-HT6 at the three cocaine doses (0.375, 0.75, and 1.5 mg/kg) (two-way ANOVA, F(1,29)=1.75, p=0.20). (c) Dose-dependent cocaine infusion (mean±SEM) for rats with Enk-GFP or Enk-5-HT6 (Enk-5-HT6 n=8–13 depending on dose; Enk-GFP n=8–13 depending on dose) at the three doses (0.375, 0.75, and 1.5 mg/kg) (two-way ANOVA, F(1,52)=16.85; p=0.0001). (d) Total cocaine received (mean±SEM) for rats with Enk-GFP or Enk-5-HT6 at the three doses (0.375, 0.75, and 1.5 mg/kg) (two-way ANOVA, F(1,52)=14.9, p=0.0003). *p<0.05, **p<0.001, and ***p<0.0001.