Table 2.
Distribution frequency of IL-18 genotypes in 559 controls and 342 patients with HCC.
| Variable | Controls (N=559) n (%) | Patients (N=342) n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| IL-18 -607A/C (rs1946518) | ||||
| AA | 148 (26.5%) | 88 (25.7%) | 1.00 | 1.00 |
| AC | 276 (49.4%) | 167 (48.8%) | 1.018 (0.734-1.410) | 0.978 (0.670-1.427) |
| CC | 135 (24.1%) | 87 (25.5%) | 1.084 (0.743-1.580) | 1.274 (0.818-1.982) |
| AC+CC | 411 (73.5%) | 254 (74.3%) | 1.039 (0.765-1.412) | 1.065 (0.747-1.520) |
| IL-18 -137G/C (rs187238) | ||||
| GG | 476 (85.2%) | 266 (77.8%) | 1.00 | 1.00 |
| GC | 78 (13.9%) | 73 (21.3%) | 1.675 (1.177-2.383)* | 2.066 (1.337-3.191)* |
| CC | 5 (0.9%) | 3 (0.9%) | 1.074 (0.255-4.528) | 1.054 (0.201-5.524) |
| GC+CC | 83 (14.8%) | 76 (22.2%) | 1.639 (1.160-2.315)* | 1.987 (1.301-3.032)* |
The odds ratios (ORs) and with their 95% confidence intervals (CIs) were estimated by logistic regression models. The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression models after controlling for age, gender, alcohol and tobacco consumption.
* p value < 0.05 as statistically significant.