Table 3.

Sensitivity of the relative increase in effects gained by co-administering ivermectin with albendazole to the transmission setting (in comparison with targeted albendazole monotherapy).

Transmission intensity	Worm years averted	Prevalent case years averted	Heavy infection case years averted — lower thresholda	Heavy infection case years averted — higher thresholda
Higher	39%	126%	36%	15%
Lower	11%	26%	4%	1%

Results pertain to a targeted preventive chemotherapy programme treating Pre-SAC and SAC with 75% treatment coverage. Two different transmission settings were explored; lower (R₀ = 1.25), and higher (R₀ = 1.75 — fitted). The analysis was performed with a ten year time horizon (i.e. comparing ten years of standalone treatment to ivermectin co-administration). Note that those under five years of age did not receive ivermectin and would only be treated with albendazole.

^aThe thresholds for heavy infection are presented in Table 1.