Table 5.
Multivariate conditional logistic regression analysis of risk factors for in-hospital mortality in patients with healthcare-associated methicillin-resistant Staphylococcus aureus bacteremia in the propensity-matched analyses
| Unmatched data set (n = 345) | Unmatched data set (IPTW, n = 345) | Matched data set (n = 254) | ||||
|---|---|---|---|---|---|---|
| Independent variable | OR (95 % CI) | P-value | OR (95 % CI) | P-value | OR (95 % CI) | P-value |
| Inappropriate empirical antibiotic therapy | 1.26 (0.64–2.48) | 0.499 | 1.33 (0.83–2.12) | 0.236 | NAa | 0.988 |
| Nosocomial infection | 2.24 (0.87–5.80) | 0.096 | 2.62 (1.28–5.37) | 0.009 | ||
| Trauma | 0.60 (0.18–1.97) | 0.398 | 0.66 (0.28–1.52) | 0.329 | 1.95 (0.50–7.56) | 0.335 |
| Surgical operation | 1.20 (0.54–2.66) | 0.656 | 1.22 (0.69–2.17) | 0.493 | ||
| Prior exposure to third- generation cephalosporins | 1.34 (0.68–2.63) | 0.399 | 1.23 (0.76–2.00) | 0.407 | 0.93 (0.41–2.10) | 0.853 |
| Prior exposure to fluoroquinolones | 0.51 (0.22–1.22) | 0.129 | 0.66 (0.35–1.24) | 0.193 | 1.24 (0.44–3.51) | 0.683 |
| Prior exposure to glycopeptides | 2.85 (1.20–6.77) | 0.018 | 2.86 (1.55–5.28) | 0.001 | 3.24 (1.08–9.67) | 0.035 |
| CR-BSI | 0.92 (0.44–1.92) | 0.825 | 0.79 (0.47–1.32) | 0.360 | ||
| Pneumonia | 0.37 (0.14–1.00) | 0.050 | 0.28 (0.14–0.59) | 0.001 | 2.15 (0.51–9.04) | 0.296 |
| Severe sepsis or septic shock | 3.84 (1.85–7.96) | <0.001 | 3.64 (2.17–6.10) | <0.001 | 5.45 (2.14–13.87) | <0.001 |
| Retention of foreign body | 1.63 (0.40–6.71) | 0.500 | 1.96 (0.62–6.18) | 0.250 | ||
| Charlson’s comorbidity index (per 1-point increment) | 0.66 (0.57–0.77) | <0.001 | 0.68 (0.61–0.75) | <0.001 | 1.52 (1.27–1.83) | <0.001 |
| Pitt’s bacteremia score (per 1-point increment) | 0.77 (0.64–0.93) | <0.001 | 0.76 (0.66–0.87) | <0.001 | 1.23 (0.99–1.54) | 0.067 |
| Age (per 1-year increment) | 0.96 (0.94–0.98) | 0.001 | 0.97 (0.95–0.98) | <0.001 | 1.02 (1.00–1.05) | 0.105 |
| Vancomycin MICs | 0.48 (0.20–1.16) | 0.103 | 0.42 (0.23–0.79) | 0.007 | 1.55 (0.52–4.62) | 0.433 |
CR-BSI catheter-related bloodstream infection, IPTW inverse probability of treatment weighted, OR odds ratio, 95 % CI 95 % confidence interval, MIC minimum inhibitory concentration, NA not available
aThese variables were not available because they displayed perfect marginal homogeneity with respect to each category concerning inappropriate initial empirical antibiotic therapy