Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PAR signaling is initiated by proteolysis of the N terminus to irreversibly activate the receptor by exposing the tethered ligand. (A-B) Proteases have distinct cleavage sites that generate unique tethered ligands that can direct the downstream signaling toward specific pathways. The PAR1 cleavage sites for thrombin, APC, MMP1, and MMP13 are shown as a representative example.
