Table 1.
Baseline demographic and clinical characteristics of enrolled patients
| Characteristics | N = 24 |
|---|---|
| Age (y) | |
| Median | 67 |
| Range | 58-85 |
| Sex, n (%) | |
| Male | 18 (75%) |
| Female | 6 (25%) |
| Rai stage, n (%) | |
| 0 | 0 (0%) |
| I-II | 7 (29%) |
| III-IV | 17 (71%) |
| Lymphocytes in bone marrow at enrollment (n = 21) | |
| Median | 80% |
| Range | 35%-95% |
| β2 microglobulin (mg/L) | |
| Median | 4.9 |
| Range | 2.4-13.7 |
| IGHV, n (%) | |
| Mutated >2% | 12 (50%) |
| Unmutated | 12 (50%) |
| NOTCH1 c.7541-7542delCT, n (%) | |
| Mutated | 3 (13%) |
| Unmutated | 17 (71%) |
| Unknown | 4 (17%) |
| TP53 mutation or 17p deletion, n (%) | |
| No | 20 (83%) |
| Yes | 4 (17%) |
| 11q deletion, n (%) | |
| No | 22 (92%) |
| Yes | 2 (8%) |
| 13q deletion, n (%) | |
| No | 8 (33%) |
| Yes | 16 (67%) |
| Trisomy 12, n (%) | |
| No | 18 (75%) |
| Yes | 6 (25%) |
| Extent of CLL, n (%) | |
| Bulky lymphadenopathy (≥1 node ≥5 cm diameter) | 7 (29%) |
| Thrombocytopenia (platelets <100 × 109/L) | 14 (58%) |
| Anemia (hemoglobin <11 g/dL) | 7 (29%) |
| Neutropenia (ANC <1.5 × 109/L) | 0 (0%) |
| Absolute lymphocyte count (×109 cells/L) | |
| Median | 44.2 |
| Range | 1.8-236.9 |
| Baseline absolute CD4+ count (×106 cells/L) | |
| Median | 1199 |
| Range | 45-6714 |
| Baseline immunoglobulin G level (mg/dL) | |
| Median | 567 |
| Range | 316-1111 |
ANC, absolute neutrophil count.