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Intracutaneous irritation test. (a) Diagram of arrangement of injection sites for tested samples (including normal saline and the BOX hydrogel at 20, 25 and 30 wt%) in rabbits. (b) Five intradermal injections of each 0.2 ml normal saline or the BOX hydrogel with different formulations (20, 25 and 30 wt%) were given to the fur-clipped skin of rabbits (N = 3). The skin irritation was evaluated at day 1, 2 and 3 after injection
