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Permeability to multiple ions is increased in S471A mutant-expressing lines. Shown is ion permeability for sodium (A), potassium (B), and chloride (C) in day 4 postconfluent parental and various S471 mutant-expressing MDCK lines. Data are expressed as means ± SD (n = 9 per condition). *, P < 0.05 compared to the S471A mutant.
