FIGURE 2.

Regulation pattern in humans, by relationship. PBMC (n = 78) from individual human subjects within a family were tested in the tvDTH assay for regulation using antigen (cell lysate) from all available family members (n = 113 total tests). Dashed line represents 25% DTH inhibition. The % inhibition of the recall response in the presence of the familial antigen is plotted with responses grouped based on the familial relationship. Offspring responding to maternal antigen show the highest level of regulation and this was significantly higher than the mother's response to offspring antigen (*P < 0.01) and one haplo mismatched sibling responses to each other (***P < 0.001).