Fig. 5.

Flow diagram of the dysfunctional mechanisms leading to LVF and HYP seizure onset. Experimental evidence taken into account for providing the mechanisms involved in LVF seizure onset was provided in the following studies: Avoli et al. 1996, Barbarosie et al. 2000, Gnatkovsky et al. 2008, Trombin et al. 2011, Grasse et al. 2013, Lévesque et al. 2016, Lopantsev et al. 1998a, Uva et al. 2015, and Ziburkus et al. 2006. Data identifying the mechanisms leading to HYP seizure onset originate from the following studies: Lopantsev and Avoli 1998b, Derchanski et al. 2006, Zhang et al. 2012, and Köhling et al. 2016.