Fig. 2.

MCN1 activates a pyloric rhythm across a large range of activity rates. A: in a subset of preparations, the pyloric rhythm was off in control conditions. B and C: in the example shown, a coordinated pyloric rhythm with regular triphasic (PD, LP, PY) activity was elicited by 5-Hz (B) and 30-Hz (C) tonic MCN1 stimulation. D: same recording as in C is shown with the gastric mill neuron, LG, digitally removed (see methods). E: cumulative data indicate that 5- and 10-Hz MCN1 activity rates activated a coordinated pyloric rhythm in some preparations, but 15-Hz and higher stimulation rates activated a coordinated pyloric rhythm in all preparations regardless of tonic or pyloric-timed MCN1 activation (15 Hz pyloric timed: n = 6; 35 Hz: n = 2; all others n = 7). **P < 0.01. ns, Nonsignificant.