Figure 1. Mouse DC subsets and precursors express T1D candidate genes: data from the ImmGen Project.

Many T1D genetic-susceptibility candidate genes are expressed in DCs. The gene expression values in mouse DC precursors and DCs for the 34 T1D candidate genes shown in Tables 1 and 2 were extracted from the mouse Immunologic Genome Project database (http://www.immgen.org) and log-transformed to be represent as a blue–red color-map across DC precursors (CMP, GMP, MDP, CDP) and different DC populations. Only genes with expression above log₂4 in at least 1 DC cell type were included. Dark blue corresponds to low or no expression in that cell type, and dark red indicates high expression. The dendrograms present genes clustered by common patterns of gene expression. CMP, common myeloid progenitor; GMP, granulocyte-monocyte progenitor; MDP, macrophage dendritic cell progenitor; CDP, common dendritic cell progenitor; SP, spleen; LN, lymph node.