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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Clin Chem. 2015 Mar 3;61(5):752–759. doi: 10.1373/clinchem.2014.235333

Table 2. Mathematics for both BV and SM models.

Total Error

 1. TE = |B| + 2I

Biological Variationa

 2. TAE=1.65(f1×CVI)+f2(CVI)2+(CVG)2
CVI = 2.77% (NGSP 1.9%)
CVG = 8.32% (NGSP 5.7%)

Classification f1 f2 TAE at HbA1c = 50 mmol/mol (6.7%)

In Relative Units (%) In Absolute Units (Concentration)

IFCC NGSP IFCC mmol/mol NGSP %

Optimum 0.25 0.125 2.24 1.53 1.1 0.10

Desirable 0.50 0.250 4.48 3.07 2.2 0.21

Minimum 0.75 0.375 6.72 4.60 3.4 0.31

Sigma-metrics

 3. σ=(TAE|B|)I

Conversion Factors NGSP from IFCC

 4. HbA1c in Concentration Units: NGSP = 0.0915IFCC + 2.15
 5. Absolute Bias in Concentrations Units: NGSP = 0.0915IFCC
 6. Imprecision in CV% at 50 mmol/mol: NGSP = 0.685IFCC
 7. Imprecision in CV% in NGSP units: IFCC = 1.46 NGSP

Symbols

 TE = Total Error in concentration units
 TAE = Total Allowable Error in concentration units
 |B| = Absolute Bias in concentration units
 I = Imprecision in concentration units
 CVI = Intra Individual Variation in CV%
 CVG = Inter Individual Variation in CV%
 σ = Chance Failure in sigma units
 f1 = Factor to classify the imprecision component of TAE
 f2 = Factor to classify the bias component of TAE
a

CVI and CVG taken from the Ricos tables in NGSP units and converted to IFCC with equation 7