Table 2. Mathematics for both BV and SM models.
Total Error | |||||||
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1. TE = |B| + 2I | |||||||
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Biological Variationa | |||||||
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2. | |||||||
CVI = 2.77% (NGSP 1.9%) | |||||||
CVG = 8.32% (NGSP 5.7%) | |||||||
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Classification | f1 | f2 | TAE at HbA1c = 50 mmol/mol (6.7%) | ||||
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In Relative Units (%) | In Absolute Units (Concentration) | ||||||
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IFCC | NGSP | IFCC mmol/mol | NGSP % | ||||
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Optimum | 0.25 | 0.125 | 2.24 | 1.53 | 1.1 | 0.10 | |
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Desirable | 0.50 | 0.250 | 4.48 | 3.07 | 2.2 | 0.21 | |
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Minimum | 0.75 | 0.375 | 6.72 | 4.60 | 3.4 | 0.31 | |
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Sigma-metrics | |||||||
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3. | |||||||
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Conversion Factors NGSP from IFCC | |||||||
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4. HbA1c in Concentration Units: | NGSP = 0.0915IFCC + 2.15 | ||||||
5. Absolute Bias in Concentrations Units: | NGSP = 0.0915IFCC | ||||||
6. Imprecision in CV% at 50 mmol/mol: | NGSP = 0.685IFCC | ||||||
7. Imprecision in CV% in NGSP units: | IFCC = 1.46 NGSP | ||||||
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Symbols | |||||||
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TE | = Total Error | in concentration units | |||||
TAE | = Total Allowable Error | in concentration units | |||||
|B| | = Absolute Bias | in concentration units | |||||
I | = Imprecision | in concentration units | |||||
CVI | = Intra Individual Variation | in CV% | |||||
CVG | = Inter Individual Variation | in CV% | |||||
σ | = Chance Failure | in sigma units | |||||
f1 | = Factor to classify the imprecision component of TAE | ||||||
f2 | = Factor to classify the bias component of TAE |
CVI and CVG taken from the Ricos tables in NGSP units and converted to IFCC with equation 7