Option A |
If CD4 cell count ≤350 cells/μL, start triple antiretrovirals at diagnosis and continue for life. If CD4 cell count >350 cells/μL start antepartum zidovudine at 14 weeks' gestation. Intrapartum: standard dose nevirapine, zidovudine and lamivudine; postpartum: zidovudine and lamivudine for 7 days |
Standard dose nevirapine daily for 6 weeks in non-breastfed infants or with mothers on antiretroviral therapy, or until 1 week after all breastfeeding has stopped |
Option B |
All HIV-infected pregnant women start triple antiretrovirals irrespective of CD4 cell count. If CD4 cell count ≤350 cells/μL, continue triple ART for life. If CD4 cell count >350 cells/μL, start triple antiretrovirals at 14 weeks' gestation and continue intrapartum and through childbirth. Stop if mother is not breastfeeding or continue until 1 week after all breastfeeding has stopped |
Daily nevirapine or zidovudine from birth to 4–6 weeks |
Option B+ |
All HIV-infected pregnant women start on triple antiretrovirals irrespective of CD4 cell count and continue for life |
Daily nevirapine or zidovudine from birth to 4–6 weeks |