Table 1.
Expiry dates for basic patents, and global price overview for HBV drugs
| Drug | Expiry datesa | US lowest priceb | Global lowest price (US$ pppy) | |
|---|---|---|---|---|
| USA | EU | |||
| Entecavir (ETV) | 2015 (invalidated 2014) | 2017 | $15,111** originator
$6,127** generic |
$427c |
| Adefovir (ADV) | 2014 | 2016 | $13,480** originator | $133c |
| Emtricitabine (FTC) | 2021 | 2016 | $6,203** originator | $62d* |
| Tenofovir disoproxil fumarate (TDF) | 2018 | 2018 | $10,718** originator | $38e*** |
| Lamivudine (3TC) | 2010 | 2010 | $2,627** originator
$1,047** generic |
$10e* |
For lamivudine, all prices are reported for doses used in treating HIV, as comparable information is only available for this dose – 150 mg. For adefovir, no global price overview exists, but the lowest price of generic adefovir in India is shown to give an impression
a
All patent dates from Gilead 2012 Form 10-K Annual Report [48];
b
goodrx.com lowest price of authorized pharmacy, including coupon discount [55]
d
Lowest price as reported by MSF[35];
e
Lowest ‘incoterms’ price as reported in the WHO's Global Price Reporting Mechanism in 2014 [33]
*
WHO prequalified;
**
USFDA approved;
***
WHO prequalified and USFDA approved; pppy: per person per year