Table 3.

Epitopes recognised by the main naturally occurring bNAbs

Antibody	Specificity	Isotype	Polyreactivity	Use in passive immunisation experiments in macaques
2F5	gp41 MPER	IgG3	Yes	No
4E10	gp41 MPER	IgG3	Yes	No
2G12	Env, glycans	IgG1	Fungal carbohydrates	Yes
1b12	CD4 binding site	IgG1	Yes	Yes
VRC01	CD4 binding site	IgG1	No	Yes
HJ16	Core/CD4 binding site	IgG1	N/A	No
PG9	V2V3 loop	IgG1	No	Yes
PG16	V2V3 loop	IgG1	No	No

MPER: membrane-proximal external region.

Adapted from [2,37].