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. 2016 Jun 21;107(7):1029–1038. doi: 10.1111/cas.12965

Figure 6.

Figure 6

Effect of panobinostat or panobinostat plus ponatinib on histone deacetylase (HDAC) activity in CML cell lines. All cell lines were treated for 12 h with the indicated concentration of panobinostat or panobinostat plus ponatinib. HDAC activity was then determined using an HDAC assay kit. Activity is indicated relative to that in the absence of treatment (100%). K562, *P = 0.026, **P = 0.023; K562/IM‐R1, *P = 0.047, **P = 0.013; Ba/F3, *P = 0.014, **P = 0.037; Ba/F3/T315I, *P = 0.025, **P = 0.041. N.S., not significant (P > 0.05).