Table 2.
Sensitivity of CML cell lines to panobinostat and/or ponatinib
| IC50 (μM) | |||||
|---|---|---|---|---|---|
| K562 | K562/IM‐R1 | Ba/F3 | Ba/F3/T315I | HL60 | |
| Panobinostat | 50.0 | 51.0 | 40.0 | 47.0 | 29.9 |
| Ponatinib | 2.0 | 3.8 | 5.0 | 30.0 | 796 |
| Combination | 0.7 | 1.3 | 3.7 | 10.0 | 32.1 |
Cells were incubated with the same concentration of panobinostat, ponatinib, or their combination for 72 h, followed by XTT assay. IC50 values, which indicate the 50% growth inhibitory concentration, are shown. HL60 cells that do not express the BCR‐ABL protein were used as a negative control.