Table 3.

Induction of apoptosis in CML cell lines by panobinostat and/or ponatinib

	Mean values (%)
	K562	K562/IM‐R1	Ba/F3	Ba/F3/T315I
Panobinostat	20.4	17.8	5.4	12.4
Ponatinib	34.1	23.3	24.7	36.7
Combination	70.3	65.4	44.9	71.9

Cells were incubated with panobinostat, ponatinib, or their combination at a concentration of 10 nM (K562 cells, K562/IM‐R1 cells, Ba/F3 cells) or 30 nM (Ba/F3/T315I cells) per agent for 48 h, followed by flow cytometric analysis of apoptosis. Apoptotic cell death was evaluated by annexin V positivity. Mean values are shown.