Table 5.
Concomitant frequent diseases classification according to inflammatory bowel disease type and the presence of extraintestinal manifestations.
| CD [%] | UC [%] | OR [95% CI] [p-value] |
EIMs [+] [%] | EIMs [-] [%] | OR [95% CI] [p-value] |
|
|---|---|---|---|---|---|---|
| Pulmonary embolism | 4/1001 [0.4] |
2/859 [0.2] |
NS | NA | NA | NS |
| Asthmaa | 6/1001 [0.6] |
9/859 [1.0] |
NS | NA | NA | NS |
| Bronchiectasis/chronic bronchitisa | 2/1001 [0.2] |
3/859 [0.3] |
NS | NA | NA | NS |
| Cholelithiasis | 80/877 [9.1] |
46/706 [6.5] |
NS | 51/527 [9.7] |
75/1056 [7.1] |
NS |
| Non-alcoholic fatty liver disease | 86/878 [9.8] |
94/706 [13.3] |
0.7 [0.5–0.9]
[0.031] |
66/527 [12.5] |
114/1057 [10.8] |
NS |
| Pancreatitis | 27/947 [2.9] |
22/820 [2.7] |
NS | 21/569 [3.7] |
28/1198 [2.3] |
NS |
| IBD-related autoimmune pancreatitis | 5/947 [0.5] |
1/820 [0.1] |
NS | 3/569 [0.5] |
3/1198 [0.3] |
NS |
| Drug-induced pancreatitis | 20/947 [2.1] |
15/820 [1.8] |
NS | 13/569 [2.3] |
22/1198 [1.8] |
NS |
| Gallstones-related pancreatitis | 2/947 [0.2] |
6/820 [0.7] |
NS | 5/569 [0.9] |
3/1198 [0.3] |
NS |
| Nephrolithiasis | 87/938 [9.3] |
61/757 [8.1] |
NS | 62/584 [10.6] |
86/1111 [7.7] |
1.4 [1.0–2.0]
[0.046] |
| Bone disease | 168/457 [36.7] |
102/363 [28.1] |
136/339 [40.1] |
134/481 [27.8] |
||
| Osteopenia | 88/457 [19.3] |
57/363 [15.7] |
NS | 67/339 [19.8] |
78/481 [16.2] |
NS |
| Osteoporosis | 80/457 [17.5] |
45/363 [12.4] |
1.5 [1.0–2.2]
[0.043] |
69/339 [20.4] |
56/481 [11.6] |
1.9 [1.3–2.8]
[0.001] |
| Anaemiab | 201/998 [20.1] |
116/858 [13.5] |
1.6 [1.2–2.1]
[< 0.0001] |
178/614 [29.0] |
139/1242 [11.2] |
3.2 [2.5–4.1]
[< 0.0001] |
| Iron deficiency anaemia | 144/998 [14.4] |
108/858 [12.6] |
NS | 147/614 [23.9] |
105/1242 [8.5] |
3.4 [2.6–4.8]
[< 0.0001] |
| Anaemia of chronic disease | 73/998 [7.3] |
14/858 [1.6] |
4.7 [2.7–8.5]
[< .0001] |
42/614 [6.8] |
45/1242 [3.6] |
1.9 [1.3–3.0]
[0.003] |
| Anaemia due to folate or vitamin B12 deficiency | 21/998 [2.1] |
2/858 [0.2] |
9.2 [2.1–39.3]
[< 0.0001] |
12/614 [2.0] |
11/1242 [0.9] |
NS |
| Diabetes mellitus | 34/1001 [3.4] |
49/859 [5.7] |
0.6 [0.4–0.9]
[0.018] |
27/615 [4.4] |
56/1245 [4.5] |
NS |
| Coronary heart disease | 19/1001 [1.9] |
59/858 [6.9] |
0.3 [0.1–0.4]
[< 0.0001] |
21/615 [3.4] |
57/1244 [4.6] |
NS |
| Multiple sclerosis | 3/1001 [0.3] |
2/859 [0.2] |
NS | 1/615 [0.2] |
4/1245 [0.3] |
NS |
| Other autoimmune diseasesc | 86/1001 [8.6] |
60/859 [7.0] |
NS | 89/615 [14.5] |
57/1245 [4.6] |
3.5 [2.5–5.0]
[< 0.0001] |
CD, Crohn’s disease; CI, confidence interval;;NS, non-significant; OR, odds ratio; UC, ulcerative colitis. Bold: significant associations.
aIn non-smokers.
bPatients with absence of beta-thalassemia and in remission of inflammatory bowel disease.
cAutoimmune thyroiditis, psoriasis, autoimmune haemolytic anemia, autoimmune hepatitis, antiphospholipidic syndrome, Biermer disease, coeliac disease, glomerulonephritis, idiopathic thrombopenic purpura, primary biliary cirrhosis, rheumatoid arthritis, sarcoidosis, Sjögren syndrome, and systemic lupus erythematosus.