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Memory performance assessed in a Morris water maze task. Trial acquisition (training): (A) latency to platform, (B) % time spent in target quadrant, (C) swim speed. Spatial reference memory (probe trial): (D) latency to platform, (E) % time spent in target quadrant, (F) swim speed. **p<0.01, ***p<0.001 (wild-type FVB/N x C57Bl/6J controls vs. vehicle-dosed hAPPLon/PS1A246E mice).
