Table 1. Absolute and relative kidney weights and urine albumin concentrations in homozygous (HOM) and heterozygous (HET) Pou3f3L423P mutant mice and control (CON) mice at 12 days of age.
| Parameter | Sex | CON (6/11) | HET (15/15) | HOM (7/5) | Statistical significance* | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CON vs. HET | CON vs. HOM | HET vs. HOM | ||||||||
| Kidney weight [mg] | M | 63 | ±11 | 60 | ±11 | 42 | ±3 | n.s. | p<0.01 | p<0.01 |
| F | 62 | ±11 | 62 | ±8 | 46 | ±8 | n.s. | p<0.01 | p<0.01 | |
| Relative kidney weight [% of body weight] | M | 1.8 | ±0.2 | 1.7 | ±0.1 | 1.5 | ±0.1 | n.s. | p<0.05 | p<0.05 |
| F | 1.8 | ±0.1 | 1.8 | ±0.2 | 1.5 | ±0.1 | n.s. | p<0.05 | p<0.05 | |
| Urine albumin concentration [μg/ml] | M | 25 | ±9 | 18 | ±6 | 18 | ±8 | n.s. | n.s. | n.s. |
| f | 19 | ±3 | 21 | ±7 | 15 | ±4 | n.s. | n.s. | n.s. | |
Numbers of animals examined are given in brackets (male/female). Data are means ± SD.
* 1-way ANOVA with Gabriel’s post hoc test. n.s. not significant.