Table 7. True harmonic mean thickness of the glomerular basement membrane (GBM) and filtration slit frequency (FSF) in homozygous (HOM) and heterozygous (HET) Pou3f3L423P mutant mice and control (CON) mice at 60 weeks of age.
| Parameter | Sex | CON (7/7) | HET (8/7) | HOM (6/6) | Statistical significance* | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CON vs. HET | CON vs. HOM | HET vs. HOM | ||||||||
| Th(GBM) [nm] | m | 178 | ±12 | 185 | ±11 | 156 | ±13 | n.s. | n.s. | p<0.05 |
| f | 164 | ±6 | 178 | ±12 | 146 | ±4 | n.s. | n.s. | p<0.05 | |
| FSF [n/mm GBM] | m | 2504 | ±194 | 2568 | ±179 | 2573 | ±67 | n.s. | n.s. | n.s. |
| f | 2560 | ±189 | 2517 | ±61 | 2631 | ±158 | n.s. | n.s. | n.s. | |
Numbers of animals examined are given in brackets (male/female). Data are means ± SD.
*:1-way ANOVA with Gabriel’s post hoc test.
a,b,c: Statistically significant differences (a: p≤0.05, b: p≤0.01, c: p≤0.001) between male and female mice of the identical genotype; n.s. not significant.