Table 2. Spearman’s correlations of exercise tolerance parameters, daily physical activity, and nutritional parameters with bone mineral density and bone turnover biomarkers in adult CF patients.
| BMD | r | p |
Bone Turnover
Biomarkers |
r | p | |
|---|---|---|---|---|---|---|
| EXERCISE TOLERANCE AND DAILY PHYSICAL ACTIVITY PARAMETERS | ||||||
| PA >3 METs | Lumbar spine Total hip Femoral neck Whole body |
0.17 0.36 0.28 0.26 |
0.254 0.01 0.048 0.047 |
P1NP PICP ALP ß-CrossLaps |
0.13 0.18 -0.01 0.13 |
0.366 0.213 0.927 0.360 |
| PA >4.8 METs | Lumbar spine Total hip Femoral neck Whole body |
0.58
0.74 0.72 0.24 |
<0.001
<0.001 <0.001 0.098 |
P1NP PICP ALP ß-CrossLaps |
0.35
0.32 0.29 0.16 |
0.013
0.023 0.043 0.266 |
| PA >7.2 METs | Lumbar spine Total hip Femoral neck Whole body |
0.20 0.49 0.34 0.21 |
0.168 <0.001 0.016 0.149 |
P1NP PICP ALP ß-CrossLaps |
0.42
0.53 0.36 0.30 |
0.003
<0.001 0.011 0.037 |
| NUTRITIONAL PARAMETERS | ||||||
|---|---|---|---|---|---|---|
| BMI (Kg/m2) | Lumbar spine Total hip Femoral neck Whole body |
0.35
0.44 0.31 0.48 |
0.015
0.001 0.028 0.001 |
P1NP PICP ALP ß-CrossLaps |
0.10 -0.13 0 -0.04 |
0.480 0.369 0.999 0.804 |
| Muscle mass (g) | Lumbar spine Total hip Femoral neck Whole body |
0.03 0.41 0.16 0.16 |
0.819 0.004 0.275 0.272 |
P1NP PICP ALP ß-CrossLaps |
0.48
0.49 0.43 0.33 |
<0.001
<0.001 0.002 0.022 |
| Fat mass (%) | Lumbar spine Total hip Femoral neck Whole body |
0.55 -0.25 -0.03 -0.00 |
0.711 0.087 0.837 0.991 |
P1NP PICP ALP ß-CrossLaps |
-0.43
-0.58 -0.37 -0.34 |
0.002
<0.001 0.010 0.017 |
| 25OHD (nmol/L) | Lumbar spine Total hip Femoral neck Whole body |
0.14 0.21 0.30 0.34 |
0.324 0.150 0.057 0.034 |
P1NP PICP ALP ß-CrossLaps |
0.06 -0.15 0.07 0.02 |
0.672 0.313 0.645 0.896 |
| VITAMIN K (μg/L) | Lumbar spine Total hip Femoral neck Whole body |
0.01 0.00 -0.04 0.07 |
0.940 0.991 0.778 0.651 |
P1NP PICP ALP ß-CrossLaps |
-0.09 -0.14 0.07 0.04 |
0.574 0.319 0.645 0.805 |
BMD: bone mineral density; METs: metabolic equivalents (minutes/day); P1NP: amino-terminal propeptide of type 1 collagen; P1CP: carboxy-terminal propeptide of type 1 collagen; ALP: bone-specific alkaline phosphatase; BMI: body mass index; 25OHD: 25-hydroxyvitamin D.