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. 2016 Feb 12;23(7):1128–1139. doi: 10.1038/cdd.2015.168

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Isolation, expansion, and differentiation of MSCs. MSCs can be isolated from various tissues of either human or mouse. This minor population of cells can be isolated, expanded, and enriched after serial passages in vitro. A combination of positive and negative markers can be used to determine the purity of MSCs. In addition to self-renewal, these multipotent MSCs can also undergo differentiation in culture. One of the gold standards for defining MSCs is their differentiation ability to cell lineages such as adipocytes and osteoblasts