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. 2016 Mar 4;23(7):1243–1256. doi: 10.1038/cdd.2016.19

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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ANXA1 enhances early and late endosome trafficking of IAV. Scramble or ANXA1-shRNA transfected A549 lung epithelial cells were infected with 1 MOI of influenza A/PR8 for the indicated time points. (a) Percentage of virus colocalized in early endosomes was quantified. (b) Number of early endosomes per cell was quantified. (c and d) Early endosomes were stained with Rab5a (green), viral NP (red) and DAPI (blue). (e) Percentage of virus colocalized in late endosomes was quantified. (f) Number of late endosomes per cell was quantified. (g and h) Late endosomes were stained with Rab7a (green), viral NP (red) and DAPI (blue). (i) Colocalization of ANXA (red) and early (Rab5a)/late (Rab7a) endosomes (green)