Figure 2.

Expression of HDAC1 and HDAC2 in full-grown oocytes, 1- and 2-cell embryos. HDAC2 is concentrated in the nucleus in oocytes, 1-cell and 2-cell embryos. HDAC1 appears in the nucleus in full-grown oocytes but then is essentially located in the cytoplasm in fertilized eggs and early 2-cell embryos. HDAC1 nuclear staining becomes clearly enriched at late 2-cell embryo stage. All samples for a given HDAC were processed for immunocytochemistry together, and all images were taken at the same laser power, thereby enabling direct comparison of signal intensities. GV, fully grown oocyte; 1C, one-cell embryo; E2C, early two-cell embryo; L2C, late two-cell embryo. Scale Bar, 25 μm