Figure 2.

Engulfment pathways regulate core apoptosis machinery in C. elegans. (a) ‘Eat-me' signals from the dying cell signals to phagocytic cell in order to initiate engulfment. Engulfment factors from engulfing cells can act to permit completion of apoptosis during development. (b) CED-1 in engulfing cells can cause CED-3 caspase gradients in dividing cells, which leads to its unequal distribution in daughter cells. This results in differential apoptotic potential