Figure 3.

Non-autonomous induction of apoptosis by other apoptotic cells. (a) During D. melanogaster development, apoptotic cells secrete Eiger to induce apoptosis of other cells through JNK-mediated pathways. Persistence of apoptotic cells can coax groups of cells that normally survive to undergo apoptosis. (b) Mammalian hair follicle cells undergo coordinated apoptosis through secretion of TNF-α by apoptotic cells. Treatment of follicle with a TNF-α neutralising antibody is sufficient to disrupt apoptosis