Figure 4.

Non-autonomous regulation of germ cell apoptosis in C. elegans. CEP-1/p53 is activated in response to DNA damage and initiates apoptosis. Permissive signal from intestinal cells (KRI-1) is required for progression of apoptotic cascade in germ cells. In contrast, accumulation of neuronal HIF-1 results in suppression of the apoptosis cascade, probably through inhibition of CEP-1. Other somatic factors such as insulin/IGF-1 signalling and the RB protein LIN-35 also contribute to apoptosis