FIGURE 3.

Effect of transgenic spermine synthase expression in Gy mice. A, polyamine content in brain. B, spermine synthase activity in brain (note log scale). C, survival. D, size. Results in panels A and B are shown as the mean ± S.E. for at least six animals. See Ref. 79 for details. This figure was modified from research originally published in the Journal of Biological Chemistry. Wang, X., Ikeguchi, Y., McCloskey, D. E., Nelson, P., and Pegg, A. E. Spermine synthesis is required for normal viability, growth and fertility in the mouse. J. Biol. Chem. 2004. 279, 51370–51375. © The American Society for Biochemistry and Molecular Biology.