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The common ΔSY mutation blocks channel surface expression. A, surface expression quantified by HA antibody binding and luminometry in COS7 cells transiently expressing external HA-tagged WT and ΔSY mutants of Kir2.3 and Kir4.1. *, p < 0.05 by unpaired t test. RLU, relative light unit. B, immunocytochemical analysis of external HA-tagged Kir2.3 and Kir4.1 channels in intact (green) and permeabilized (red) COS7 cells, counterstained with DAPI (blue) to show nuclei.
