FIGURE 1.
Fenamic acid derivatives bound in the cyclooxygenase channel of human COX-2. Simulated annealing FO - FC omit maps (blue), contoured at 3σ for meclofenamic acid (A), mefenamic acid (B), flufenamic acid (C), and tolfenamic acid (D) bound within the cyclooxygenase channel of monomer B in each complex. For each drug, carbon, nitrogen, and oxygen atoms are colored yellow, blue, and red, respectively. The chlorine atoms in meclofenamic acid and tolfenamic acid are colored green, whereas the fluorine atoms in flufenamic acid are colored cyan. Residues lining the cyclooxygenase channel are labeled accordingly.