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. 2016 May 26;291(29):15256–15266. doi: 10.1074/jbc.M116.722967

FIGURE 2.

FIGURE 2.

Inhibition of tankyrase stabilizes AMOT family proteins. A, proteomics strategy to identify tankyrase substrates. B, scatter plot depicting proteins identified and quantified in a quantitative proteomics experiment. Proteins significantly depleted in XAV939-treated condition are highlighted as potential substrates of tankyrase. C, tankyrase inhibitors increase protein levels of AMOT p130 and AMOTL1. D, depletion of TNKS1/TNKS2 or RNF146 increases the protein level of AMOT p130. E, proteasome inhibitor MG132 increases protein levels of AMOT p130 and AMOTL1. F, tankyrase inhibitor increases half-life of HA-AMOTL1. G, tankyrase inhibitor suppresses PARsylation of AMOT p130.