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The tankyrase binding motif is required for tankyrase-induced degradation of angiomotins. A, schematic diagram of the domain structure of angiomotins. The tankyrase binding motif at the N terminus of angiomotins is indicated. B, angiomotins interact with tankyrase through the N-terminal tankyrase binding motif. C, mutation of tankyrase binding motif stabilizes AMOT and AMOTL1.
