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Knock-out of angiomotins abolishes the inhibitory activity of tankyrase inhibitor on YAP signaling. A, protein levels of AMOT and AMOTL1 are decreased in 293A GTIIC-GFP Cas9 cells expressing gRNAs against angiomotins. B, knock-out of angiomotins abolishes the inhibitory effect of tankyrase inhibitor on GTIIC-GFP. C, knock-out of angiomotins attenuates the inhibitory activity of tankyrase inhibitor on YAP target genes.
