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. 2016 May 26;291(29):15256–15266. doi: 10.1074/jbc.M116.722967

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Tankyrase inhibitor TNKS656, but not porcupine inhibitor WNT974, sensitizes NSCLC cells to EGFR inhibitor Erlotinib. A and B, checkbox assays were performed to measure growth inhibitory effect of combination of Erlotinib and TNKS656 (A) or WNT974 (B) in PC9, HCC827, and HCC4006 cells, and Loewe synergy scores were calculated. Loewe Synergy score above 2 is considered significant. C, effects of TNKS656 and WNT974 on YAP target genes (CTGF and ANKRD1) and β-catenin target genes (AXIN2 and NKD1).