FIGURE 1.

Molecular representation of human Cyt c and bovine CcO. a, structure of human Cyt c (red schematic) with the residues (spheres) targeted by in vitro mutagenesis. In detail, the mutated residues in groups A–C, reflecting the degree of mutational effects (severe, moderate, and unaffected, respectively), are represented by magenta, cyan, and green spheres, respectively. b, structure of bovine CcO with the three important catalytic subunits I–III represented by green, cyan, and magenta, respectively. c, blue region of CcO used for docking includes the part (partial residues in subunits I–IV and VII–XIII) occupying the intermembrane space and the adjacent membrane-embedded region. In CcO, heme groups and copper ions are represented in spheres.