FIGURE 3.

Predicted binding interfaces of the Cyt c-CcO complexes of poses 1 and 13. a, focused view of the heme c (sphere) in Cyt c and Trp-104 (stick) in CcO, the probable electron entry site obtained from pose 1. b, interactions of the mutated residues in Cyt c with contact residues in CcO from pose 1 are highlighted. The amino acid residues in subunits I, II, and III are represented by green, cyan, and magenta (sticks), respectively. Dotted lines indicate hydrogen bonding between Cyt c and CcO residues. c and d, same representation as in a and b, respectively, but the corresponding CcO is from pose 13.