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. 2016 May 20;291(29):15358–15377. doi: 10.1074/jbc.M116.718544

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Phylogenetic tree based on alignment of amino acid sequences for mouse and human Tas2r and their chromosomal localization. After a multiple sequence alignment of the Tas2r manually adjusted to consider the potential tertiary structure, a neighbor-joining tree was constructed. Percentage of bootstrap values higher than 50 are displayed as node labels. Tas2r are classified into five clusters. Glires cluster I represents a species- and lineage-specific cluster of 11 mouse receptors and human TAS2R14, whereas muroid clusters I and II comprise five mouse Tas2r connected to TAS2R10 and three mouse Tas2r associated with TAS2R13, respectively. The anthropoid cluster represents human cluster composed of eight TAS2R related to the Glires cluster II comprising Tas2r120 and Tas2r136.