FIGURE 1.

A, hepatic Fgf21 expression and serum concentrations in Ahr^Fx/Fx and Cre^AlbAhr^Fx/Fx mice. B, hepatic Fgf21 expression in C57BL6/J and Ahr-null mice. C, expression of Fgf21 target gene Igfbp1. D, hepatic expression of genes involved in de novo lipogenesis. E, Fgf21 expression and F, de novo lipogenesis gene expression in adipose tissue from Ahr^Fx/Fx and Cre^AlbAhr^Fx/Fx mice. G, hepatic Fgf21 mRNA and serum FGF21 levels in fasted Ahr^Fx/Fx mice, exposed to vehicle or 10 μg/kg of TCDD by gavage. Fasn, fatty acid synthase; Scd1, stearoyl-CoA desaturase 1; Srebp1c, sterol response element-binding protein 1c. All data are presented as mean ± S.E. from three or more mice. Statistical analyses were performed using either a two-tailed Student's t test or one-way ANOVA. The latter analysis was performed when there were more than two treatment groups; *, p < 0.05; **, p < 0.01. These experiments have been repeated twice.