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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Pain. 2016 Apr;157(4):806–817. doi: 10.1097/j.pain.0000000000000439

Figure 8. Intrathecal astroglial inhibitor L-alpha aminoadipate (L-AA, 100 nmol) reduces chronic itch and alloknesis without affecting acute itch.

Figure 8

(A) Acute itch induced by compound 48/80 (48/80, 100 μg) and chloroquine (CQ, 200 μg) is not affected intrathecal L-AA. n = 6 mice per group. (B) 48/80-induced alloknesis is inhibited by intrathecal L-AA. *P<0.05, **P<0.01, compared with saline control, n = 6 mice per group. (C–D) AEW-induced chronic itch (C) and alloknesis (D) is suppressed by intrathecal L-AA. **P<0.01, ***P<0.001, compared with saline control, Student’s t test; n = 6 mice per group. Data are presented as means ± S.E.M.