Table 1.

Clincal data for cases of IgE-mediated reactions to vancomycin (n=7)

	Age (yrs)	Gender (M/F)	Number of vancomycin doses previously	Infection treated	Reaction timing* (minutes)	Symptoms	Treatment	Outcome	Skin- testing or re- challenge	Justification for IgE
Otani et al. 2015	60	F	NA	Enterococcus faecalis	8m	Dyspnea Hypotension Skin erythema Flushing	Steroids Antihistamines Epinephrine	Improved	Yes	Skin testing positive
Bosse et al. 2013	35	M	1	Clostridium difficile colitis	35m	Dyspnea Throat tightness, laryngeal edema, Facial erythema	Steroids IVF Antihistamines Epinephrine Switched therapy	Improved	No	Convincing clinical diagnosis
Kupsta ie et al. 2010	23	M	1	Polymicrobia l bactermia including Enterococcus faecalis and MRSA	1m	Dyspnea Hypotension (80/60) Tachycardia Facial flushing, cold sweat, tremor	Steroids IVF Antihistamines Switched therapy	Improved, negative repeat culture	No	Convincing clinical diagnosis
Kitaza wa et al. 2005	43	M	1	MRSA abscess	1m	Wheezing Flushing	Antihistamines	Improved	Yes	Breakthrough symptoms despite premedication and desensitization
Hassab alla et al. 2000	45	F	NA	Enterococcus wound infection	1m	Cardiac arrest Hypotension Flushing Tongue swelling Emesis, Diaphoresis	Intubated Epinephrine Steroids Antihistamines Desensitized to vancomycin	Improved	No	Convincing clinical diagnosis
Chopra et al. 2000	46	F	1	MRSA dialysis catheter infection	2m	Respiratory distress, Wheezing, Cyanosis, Pruritus, Erythema,	Steroids Antihistamines	Deceased, from sepsis	Yes	Severe reaction despite red man syndrome prophylactic administration
Vilavic encio et al. 1998	43	F	1	MRSA wound infection	2m	Hypotension, Facial swelling, Lip Swelling	CPR Intubation Epinephrine	Improved	Yes	Severe reaction with breakthrough symptoms despite premedication and desensitization

^*Timing from vancomycin dose to reaction onset

Abbreviations: NA: not available; IVF: intravenous fluids; MRSA: methicillin-resistant Staphylococcus aureus; CPR: cardiopulmonary resuscitation