Table 1.
Treatment | Placental wt (gm) | Body wt (gm) | Glucose (mg/dl) | Insulin (μIU/ml) |
---|---|---|---|---|
Untreated | 183 ± 9 | 810 ± 27 | 74 ± 6 | 3.7 ± 0.3 |
Letrozole | 207 ± 16* | 790 ± 62 | 70 ± 8 | 4.1 ± 0.4 |
Letrozole + estradiol | 176 ± 12 | 767 ± 59 | 75 ± 7 | 3.9 ± 0.7 |
Values are expressed as means ± SE on the day of delivery (days 165–175 of gestation) in newborns from baboons untreated (n=10) or treated on days 100–165/175 of gestation (term = 184 days) with letrozole (115 μg/kg body weight/day via maternal sc injection, n=5) or letrozole (115 μg/kg body weight) plus estradiol (25 to 115 μg/kg body weight/day, n=4).
P<0.05 versus untreated.