. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: J Endocrinol. 2016 May 20;230(2):171–183. doi: 10.1530/JOE-15-0530

Table 3.

Blood glucose and plasma insulin levels in baboon offspring after an iv glucose tolerance test

Treatment	Glucose (mg/dl)		Glucose (AUC)	Insulin (μIU/ml)		Insulin (AUC)	Glucose AUC Insulin AUC
Treatment	Mean 1+3+5 min	Mean 1+3+5 min - baseline	Glucose (AUC)	Mean 1+3+5 min	Mean 1+3+5 min - baseline	Insulin (AUC)	Glucose AUC Insulin AUC
Untreated	165 ± 4^a	99 ± 5	977 ± 34^a	32.4 ± 3.8^a	26.6 ± 4.4^a	192 ± 23^a	5.84 ± 0.72^a
Letrozole	183 ± 4^b	114 ± 5^*	1098 ± 21^b	77.7 ± 13.6^b	65.4 ± 11.7^b	574 ± 85^b	2.04 ± 0.25^b
Letrozole + estradiol	169 ± 2^a,b	99 ± 5	1006 ± 10^a,b	53.2 ± 3.7^a,b	44.9 ± 2.2^a,b	318 ± 22^c	3.24 ± 0.27^a

Values are the means ± SE of the average levels of blood glucose and plasma insulin at 1, 3 and 5 min, area under curve (AUC) for glucose and insulin, and ratio of glucose AUC ÷ insulin AUC after an iv bolus of dextrose to prepubertal offspring from baboons untreated (n=10) or treated with letrozole (n=5), or letrozole plus estradiol (n=4). Values with different letters are different from each other (P<0.05, glucose: P<0.01, insulin; ANOVA, Tukey-Kramer Multiple Comparison test).

P=0.07 versus untreated or letrozole plus estradiol-treatment (ANOVA, Kruskal-Wallis test).